Sodium Hydroxide → HCID 15572236, compound

HRID 2286601Notes

Reaction equation

HRID 2286601 reaction equation
[CH:1]([C:4]1[CH:9]=[C:8]([C:10]([OH:19])([C:15]([F:18])([F:17])[F:16])[C:11]([F:14])([F:13])[F:12])[CH:7]=[C:6]([CH:20]([CH3:22])[CH3:21])[C:5]=1[NH:23][CH2:24][C:25]([O:27]CC)=[O:26])([CH3:3])[CH3:2].[OH-].[Na+]>Cl>[C:25]([CH2:24][NH:23][C:5]1[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][C:8]([C:10]([OH:19])([C:15]([F:17])([F:16])[F:18])[C:11]([F:14])([F:12])[F:13])=[CH:7][C:6]=1[CH:20]([CH3:22])[CH3:21])([OH:27])=[O:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15572223HCID 15572223, compound

Product 1

HCID 15572236HCID 15572236, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Stirr ethyl N-[2,6-diisopropyl-4-(hexafluoro-2-hydroxy-2-propyl)phenyl]glycinate (5.0 g, 12 mmol) with 50 ml 1.0 N NaOH for 1 hour. Neutralize the solution with 50 ml 1.0 N HCl. Filter the solid, dissolve in ether, dry and concentrate. Recrystallize from ether-hexane to obtain the title compound as a white solid, m.p. 130°-132° C.

Workup

  1. filtrationFilter the solid
  2. dissolutiondissolve in ether
  3. customdry
  4. concentrationconcentrate
  5. customRecrystallize from ether-hexane

Sources & evidence

ORD record
ord-876fef8aafc14a45a095b54eb42916f7
Source dataset
uspto-grants-1981_05
Patent number
US04267193

Reaction notes

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