1,1'-Carbonyldiimidazole → HCID 178474788, compound

HRID 2286615Notes

Reaction equation

HRID 2286615 reaction equation
[C:1]([NH:4][C:5]([CH3:26])([CH3:25])[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[C:19]([OH:21])[C:18]([C:22]([OH:24])=[O:23])=[CH:17][N:16]=2)=[CH:11][CH:10]=1)=[O:7])(=[O:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O>O1CCCC1>[N-:20]1[CH:19]=[CH:18][N:16]=[CH:15]1.[C:1]([NH:4][C:5]([CH3:26])([CH3:25])[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:20]=[C:19]([OH:21])[C:18]([C:22]([OH:24])=[O:23])=[CH:17][N:16]=2)=[CH:13][CH:14]=1)=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 178474787HCID 178474787, compound

Product 1

HCID 178474788HCID 178474788, compoundYield 142.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 5.6 g (15.7 mmol) of the above pyrimidine acid and 5.0 g (31 mmol) of carbonyldiimidazole in 100 ml tetrahydrofuran is stirred at 50° C. for 1/2 hr and at room temperature for 2 hrs. The mixture is filtered and the solids washed with ether and dried in vacuo affording 4.75 g of the title imidazolide.

Workup

  1. filtrationThe mixture is filtered
  2. washthe solids washed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e04ce5aff7764a3596df15db0b505689
Source dataset
uspto-grants-1981_05
Patent number
US04267180

Reaction notes

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