反应详情

In 100 ml of dimethylacetamide were dissolved 19.51 g (0.15 mol) of 5-fluorouracil and 75.90 g (0.75 mol) of triethylamine. To this mixture was added dropwise at room temperature 41.05 g (0.165 mol) of chloromethyl laurate and the mixture was reacted together for 20 hours. After completion of the reaction, the triethylamine and dimethylacetamide were removed by distillation and the residue was poured into 400 ml of water. The mixture was stirred, filtered and washed with water whereby crystals were obtained which were then recrystallized from 200 ml of ethanol to obtain 38.06 g of 1-lauroyloxymethyl-5-fluorouracil having a melting point of 113.7~114.2° C. in a yield of 74.2%.

1. customthe mixture was reacted together for 20 hours
2. customAfter completion of the reaction
3. customthe triethylamine and dimethylacetamide were removed by distillation
4. additionthe residue was poured into 400 ml of water
5. filtrationfiltered
6. washwashed with water whereby crystals
7. customwere obtained which
8. customwere then recrystallized from 200 ml of ethanol