Hydrochloric Acid → 7631-35-8

HRID 2286704Notes

Reaction equation

HRID 2286704 reaction equation
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].[OH-:12].[K+:13].Cl>O>[NH2:1][C:11]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:4](=[O:5])[C:2]([O-:12])=[O:3].[K+:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7054IsatinHCID 14797Potassium Hydroxide

Product 1

HCID 236813967631-35-8Yield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 250 mL one-necked flask was charged with 18.3 grams of isatin (0.124 mol), 37.1 mL. of 30% potassium hydroxide (0.196 mol) and 50 mL of water. The mixture was stirred at room temperature for 6 hours. At the end of this time, the pH of the mixture was adjusted to 7.36 by the addition of 10% hydrochloric acid. Water was removed from the mixture by means of a rotary evaporator, and the crude potassium 2-aminophenylglyoxylate obtained in this manner was dried in a desicator. The crude, dried material weighed 22.1 grams, indicating a yield of 87 percent.

Workup

  1. customWater was removed from the mixture by means of a rotary evaporator

Sources & evidence

ORD record
ord-bacb3c8593b4436b8d17992ac15f7829
Source dataset
uspto-grants-1981_05
Patent number
US04267333

Reaction notes

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