Phosphorus oxychloride → HCID 12436995, compound

HRID 2286710Notes

Reaction equation

HRID 2286710 reaction equation
[C:1]1([N:7]2[C:11](=O)[CH2+:10]=[CH:9][S:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:15])=O>CCOCC>[Cl-:15].[C:1]1([N+:7]2[S:8][CH:9]=[CH:10][C:11]=2[Cl:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 24813Phosphorus oxychloride

Product 1

HCID 12436995HCID 12436995, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
60 °C

Procedure

2-Phenyl-4-isothiazolium-3-one (J. Het. Chem., 8, 571 (1971)) (1 g.) is stirred at room temperature with phosphorous oxychloride (3-5 ml.); the progress of the reaction was monitored by TLC for disappearance of starting material. The reaction can be speeded up by warming to 60° C. Ether is added to precipitate a white gum. The residue was flushed once more with ether and decanted. The material is used as such in the next step.

Workup

  1. customThe reaction
  2. customto precipitate a white gum
  3. customThe residue was flushed once more with ether
  4. customdecanted

Sources & evidence

ORD record
ord-90fb618c42064f4bb6c61d55d0d11bc3
Source dataset
uspto-grants-1981_05
Patent number
US04267341

Reaction notes

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