反应详情

温度

20 °C

157 g (0.79 mol) of 1-bromo-3,3-dimethyl-4-fluoro-2-butanone were added dropwise to a stirred mixture of 102 g (0.79 mol) of p-chlorophenol and 110 g (0.79 mol) of powered potassium carbonate in 500 ml of acetone at 20° to 30° C., while cooling. The mixture was subsequently stirred at 20° C. for 2 hours, the inorganic salt was filtered off and the filtrate was concentrated. The residue was distilled under a high vacuum. 175 g (90% of theory) of 1-(4-chlorophenoxy)-3,3-dimethyl-4-fluoro-2-butanone of boiling point 112° to 119° C./0.05 mm Hg were obtained. ##STR15##

1. temperaturewhile cooling
2. filtrationthe inorganic salt was filtered off
3. concentrationthe filtrate was concentrated
4. distillationThe residue was distilled under a high vacuum