反应详情

28 parts of dibutylamine and 25 parts of triethylamine are added to 27 parts of 2-amino-5-chloro-1,3,4-thiadiazole in 200 parts of ethanol. The reaction mixture is heated under reflux for 2 hours and then concentrated to dryness. The residue is suspended in 250 ml of water and filtered. The 2-amino-5-dibutylamino-1,3,4-thiadiazole obtained in this manner can be recrystallised from ethanol/water. Melting point: 116°-117°

1. temperatureThe reaction mixture is heated
2. temperatureunder reflux for 2 hours
3. concentrationconcentrated to dryness
4. filtrationfiltered