反应详情

温度

100 °C

4-(2-Iodo-4,5-dimethyl-phenoxy)-6,7-dimethoxyquinoline (compound 164) (59 mg), pyridine-3-boronic acid (33 mg), and tetrakistriphenylphosphine palladium (10 mg) were dissolved in N,N-dimethylformamide (4 ml), a 2 M aqueous potassium carbonate solution (0.5 ml) was added to the reaction system, and the mixture was stirred at 100° C. for 30 min. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure. The residue was purified by thin layer chromatography using acetone-chloroform to give the title compound (13 mg, yield 25%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe ethyl acetate layer was then washed with water
3. dry with materialwas dried over anhydrous sodium sulfate
4. customThe solvent was removed
5. distillationby distillation under the reduced pressure
6. customThe residue was purified by thin layer chromatography