Tetrahydrofuran → HCID 178499190, compound

HRID 2286994Notes

Reaction equation

HRID 2286994 reaction equation
Cl[C:2]1[S:6][N:5]=[C:4]([C:7]([O:9][CH3:10])=[O:8])[N:3]=1.NC(N)=[S:13].O1CCCC1>O>[SH:13][C:2]1[S:6][N:5]=[C:4]([C:7]([O:9][CH3:10])=[O:8])[N:3]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 2723790ThioureaHCID 233241991,2,4-Thiadiazole-3-carboxylic acid, 5-chloro-, methyl ester

Product 1

HCID 178499190HCID 178499190, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of methyl 5-chloro-1,2,4-thiadiazole-3-carboxylate (7.80 g), thiourea (3.32 g), tetrahydrofuran (24 ml) and water (8 ml) was gently boiled for 6.5 hours. The reaction mixture was post-treated according to conventional manner to give yellow powder of methyl 5-mercapto-1,2,4-thiadiazole-3-carboxylate (7.1 g), mp. 126° to 127° C.

Workup

  1. additionThe reaction mixture was post-treated

Sources & evidence

ORD record
ord-8ef32de6afba4bcfbacf035a7ffc4d05
Source dataset
uspto-grants-1981_05
Patent number
US04268509

Reaction notes

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