Hydroxyamine hydrochloride → HCID 12876705, compound

HRID 2287027Notes

Reaction equation

HRID 2287027 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][CH:11]([C:16](=O)[CH2:17][CH3:18])[C:12](=[O:15])[CH2:13][CH3:14].Cl.[NH2:21]O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]1[C:16]([CH2:17][CH3:18])=[N:21][O:15][C:12]=1[CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 3007343HCID 3007343, compound

Product 1

HCID 12876705HCID 12876705, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-[(2-Chloro-4-methoxyphenyl)methyl]-3,5-diethylisoxazole [I; Ar is 2-Cl-4-CH3OC6H3, Y is CH2, R is C2H5 ] was prepared from 30.9 g. of 4-[(2-chloro-4-methoxyphenyl)methyl]-3,5-heptanedione and 7.96 g. of hydroxylamine hydrochloride in 65 ml. of pyridine according to the procedure of Example 2, part (b), and was obtained in the form of a pale yellow oil, b.p. 144°-147° C. (0.08 mm.); yield 21.6 g.; MIC=12 μg/ml (herpes 2).

Sources & evidence

ORD record
ord-d807be3744254dffba297fe21f5e2f59
Source dataset
uspto-grants-1981_05
Patent number
US04268678

Reaction notes

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