Hydroxyamine hydrochloride → HCID 5271170, compound

HRID 2287028Notes

Reaction equation

HRID 2287028 reaction equation
[CH3:1][O:2][C:3]1[CH:24]=[CH:23][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([C:19](=O)[CH2:20][CH3:21])[C:15](=[O:18])[CH2:16][CH3:17])=[C:5]([N+:25]([O-:27])=[O:26])[CH:4]=1.Cl.[NH2:29]O>N1C=CC=CC=1>[CH2:20]([C:19]1[C:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][O:7][C:6]2[CH:23]=[CH:24][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[N+:25]([O-:27])=[O:26])=[C:15]([CH2:16][CH3:17])[O:18][N:29]=1)[CH3:21]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 514072HCID 514072, compound

Product 1

HCID 5271170HCID 5271170, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3,5-Diethyl-4-[6-(4-methoxy-2-nitrophenoxy)hexyl]isoxazole [I; Ar is 2-O2N-4-CH3OC6H3, Y is O(CH2)6, R is C2H5 ] was prepared from 10.0 g. of 4-[6-(4-methoxy-2-nitrophenoxy)hexyl]-3,5-heptanedione and 2.0 g. of hydroxylamine hydrochloride in 40 ml. of pyridine according to the procedure of Example 2, part (b), and was obtained in the form of a yellow oil, b.p. 200°-205° C. (0.02 mm.); yield 7.5 g.; MIC=3 μg/ml (herpes 2).

Sources & evidence

ORD record
ord-69aee46246fa498da377b84124bca3d8
Source dataset
uspto-grants-1981_05
Patent number
US04268678

Reaction notes

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