Hydroxyamine hydrochloride → HCID 13078361, compound

HRID 2287029Notes

Reaction equation

HRID 2287029 reaction equation
[Br:1][C:2]1[CH:23]=[CH:22][C:5]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([C:18](=O)[CH2:19][CH3:20])[C:14](=[O:17])[CH2:15][CH3:16])=[CH:4][CH:3]=1.Cl.[NH2:25]O>N1C=CC=CC=1>[Br:1][C:2]1[CH:23]=[CH:22][C:5]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[C:18]([CH2:19][CH3:20])=[N:25][O:17][C:14]=2[CH2:15][CH3:16])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 514045HCID 514045, compound

Product 1

HCID 13078361HCID 13078361, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-[6-(4-Bromophenoxy)hexyl]-3,5-diethylisoxazole [I; Ar is 4-BrC6H4, Y is O(CH2)6, R is C2H5 ] was prepared from 10.0 g. of 4-[6-(4-bromophenoxy)hexyl]-3,5-heptanedione and 2.0 g. of hydroxylamine hydrochloride in 40 ml. of pyridine according to the procedure of Example 2, part (b), and was obtained in the form of a pale yellow oil, b.p. 190°-195° C. (0.001 mm.); yield 7.3 g.; MIC=12 μg/ml (herpes 2).

Sources & evidence

ORD record
ord-3c5afdaaf739491ea0ac64cc31f689c8
Source dataset
uspto-grants-1981_05
Patent number
US04268678

Reaction notes

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