Hydroxyamine hydrochloride → HCID 13078362, compound

HRID 2287030Notes

Reaction equation

HRID 2287030 reaction equation
[Cl:1][C:2]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:14](=O)[CH2:15][CH3:16])[C:10](=[O:13])[CH2:11][CH3:12].Cl.[NH2:25]O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[C:14]([CH2:15][CH3:16])=[N:25][O:13][C:10]=1[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 514086HCID 514086, compound

Product 1

HCID 13078362HCID 13078362, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-[4-(2-Chloro-4-methoxyphenoxy)butyl]-3,5-diethylisoxazole [I; Ar is 2-Cl-4-CH3OC6H3, Y is O(CH2)4, R is C2H5 ] was prepared from 16.2 g. of 4-[4-(2-chloro-4-methoxyphenoxy)butyl]-3,5-heptanedione and 3.3 g. of hydroxylamine hydrochloride in 65 ml. of pyridine according to the procedure of Example 2, part (b), and was obtained in the form of a yellow oil, b.p. 180°-190° C. (0.1 mm.); yield 9.3 g.; MIC=6 μg/ml (herpes 2).

Sources & evidence

ORD record
ord-32508c845de0488c957d475ccef574a1
Source dataset
uspto-grants-1981_05
Patent number
US04268678

Reaction notes

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