反应详情

温度

120 °C

4-Chloro-2-hydroxyacetophenone (45 mg), 4-chloro-6,7-dimethoxyquinoline (60 mg), and 4-dimethylaminopyridine (95 mg) are suspended in o-dichlorobenzene (10 ml) to prepare a suspension which was then stirred at 120° C. overnight and then at 140° C. for 5 hr. The reaction solution was cooled to room temperature, and the solvent was removed by distillation under the reduced pressure. Water was then added to the residue, and the mixture was extracted with chloroform. The chloroform layer was washed with water and was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using acetone-hexane to give the title compound (11 mg, yield 12%).

1. customto prepare a suspension which
2. waitat 140° C. for 5 hr
3. temperatureThe reaction solution was cooled to room temperature
4. customthe solvent was removed by distillation under the reduced pressure
5. additionWater was then added to the residue
6. extractionthe mixture was extracted with chloroform
7. washThe chloroform layer was washed with water
8. dry with materialwas dried over anhydrous sodium sulfate
9. customthe solvent was removed by distillation under the reduced pressure
10. customthe residue was purified by thin layer chromatography