Pyridine-2-carbonitrile → HCID 23459576, compound

HRID 2287208Notes

Reaction equation

HRID 2287208 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1)#[N:2].C(C1C=CC=CN=1)#N.[CH3:18][C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[C:21]#[N:22].[Cl:27]C1C=CC(C#N)=C(C)C=1>>[ClH:27].[NH2:22][C:21]1[C:20]2[C:19](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[C:1]([C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=2)[N:2]=1

Participants

5

Reactant 4

HCID 7522Pyridine-2-carbonitrileHCID 107212-MethylbenzonitrileHCID 741826-Methylpyridine-2-carbonitrileHCID 1427424-Chloro-2-methylbenzonitrile

Product 1

HCID 23459576HCID 23459576, compound

Procedure

Using the method of Example VII, but substituting 2-cyano-6-methylpyridine for the 2-cyanopyridine and 2-methylbenzonitrile for the 4-chloro-2-methylbenzonitrile, there was obtained 1-amino-3-(6-methyl-2-pyridyl)-isoquinoline hydrochloride. The compound was crystallized from isopropyl alcohol. Melting point 263.5°-264.5° C.

Sources & evidence

ORD record
ord-eea90acce54c45feb8947291183e3099
Source dataset
uspto-grants-1981_05
Patent number
US04269834

Reaction notes

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