Benzoyl chloride → HCID 13384145, compound

HRID 2287212Notes

Reaction equation

HRID 2287212 reaction equation
Cl.C[C:3]1[N:8]=[C:7]([C:9]2[NH:10][C:11](=[O:19])[C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:6]=[CH:5][CH:4]=1.C(Cl)(=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:17]1([CH2:18][CH:9]([NH:10][C:11](=[O:19])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:7]2[CH:6]=[CH:5][CH:4]=[CH:3][N:8]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 13384132HCID 13384132, compound

Product 1

HCID 13384145HCID 13384145, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The amine prepared as described in (a) was dissolved in chloroform and equivalent amounts of benzoyl chloride and triethylamine were added. The reaction mixture was refluxed for two hours and then washed with water and dried with sodium sulphate. The solvent was distilled off and the residue crystallised from ethanol to yield N-[2-phenyl-1-(2-pyridyl)ethyl]benzamide.

Workup

  1. temperatureThe reaction mixture was refluxed for two hours
  2. washwashed with water
  3. dry with materialdried with sodium sulphate
  4. distillationThe solvent was distilled off
  5. customthe residue crystallised from ethanol

Sources & evidence

ORD record
ord-ab96334872224ff590e618037372af1b
Source dataset
uspto-grants-1981_05
Patent number
US04269834

Reaction notes

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