Ethane, 2-bromo-1,1-diethoxy- → HCID 15888248, compound

HRID 2287354Notes

Reaction equation

HRID 2287354 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[N:11]1[C:20]2[N:19]=[C:18]([CH3:21])[N:17]=[C:16]([N:22]([CH2:27][CH3:28])[CH2:23][CH2:24][CH2:25][CH3:26])[C:15]=2[NH:14][C:13](=[NH:29])[CH2:12]1.[CH2:30](OC(OCC)CBr)[CH3:31]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[N:11]1[C:20]2[C:15](=[C:16]([N:22]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:27][CH3:28])[N:17]=[C:18]([CH3:21])[N:19]=2)[N:14]2[CH:30]=[CH:31][N:29]=[C:13]2[CH2:12]1

Participants

4

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 178449019HCID 178449019, compound

Product 1

HCID 15888248HCID 15888248, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the compound of Example 248 and a slight excess of bromoacetaldehyde diethyl acetal in ethanol is heated to reflux until the starting material is consumed. The reaction mixture is evaporated, and the residual material is purified by chromatography or recrystallization to afford the title product.

Workup

  1. temperatureto reflux until the starting material
  2. customis consumed
  3. customThe reaction mixture is evaporated
  4. customthe residual material is purified by chromatography or recrystallization

Sources & evidence

ORD record
ord-b4c674b4816f4a8fbcd90c27afdcb813
Source dataset
uspto-grants-2000_07
Patent number
US06083948

Reaction notes

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