反应详情

Sodium (181 mg) was dissolved in 10 ml of methanol and 400 mg of N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide was added with stirring at room temperature. The reaction mixture was stirred at room temperature for three hours and poured into a mixture of 1N hydrochloric acid and ice. The crystals separated out therefrom were collected by filtration and the resulting crystals were purified by a silica gel column chromatography (chloroform-methanol=40:1). The resulting yellow amorphous substance was crystallized in ether and collected by filtration to give 273 mg of N-[6-methoxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamide.

1. stirringThe reaction mixture was stirred at room temperature for three hours
2. customThe crystals separated out
3. filtrationtherefrom were collected by filtration
4. customthe resulting crystals were purified by a silica gel column chromatography (chloroform-methanol=40:1)
5. customThe resulting yellow amorphous substance was crystallized in ether
6. filtrationcollected by filtration