反应详情

To a solution of 4-benzyloxy-1-methyl-2-methylamino-1H-benzimidazole (200 mg) in dimethylformamide (2 ml) was added sodium hydride (32.9 mg) under ice-cooling, and the mixture was stirred for 15 minutes. To the mixture was added methyl iodide (127 mg), and the mixture was stirred for 15 minutes under ice-cooling and then for 2 hours at ambient temperature. Water was added to the reaction mixture, and extracted with chloroform. The organic layer was dried over magnesium sulfate and evaporated in vacuo. The residue was purified by flash chromatography (chloroform:methanol=50:1, v/v) to give 4-benzyloxy-1-methyl-2-dimethylamino-1H-benzimidazole (100 mg).

1. temperaturecooling
2. stirringthe mixture was stirred for 15 minutes under ice-
3. temperaturecooling
4. waitfor 2 hours at ambient temperature
5. extractionextracted with chloroform
6. dry with materialThe organic layer was dried over magnesium sulfate
7. customevaporated in vacuo
8. customThe residue was purified by flash chromatography (chloroform