Water → HCID 15588674, compound

HRID 2287586Notes

Reaction equation

HRID 2287586 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[C:16]2[O:15][C:14](=[O:17])[NH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1.[C:18](=O)([O-])[O-].[K+].[K+].CI.O>CN(C)C=O>[CH3:18][N:13]1[C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([O:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)[C:16]=2[O:15][C:14]1=[O:17]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 15588673HCID 15588673, compound

Product 1

HCID 15588674HCID 15588674, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a suspension of 7-(tetrahydropyran-2-yloxy)-2(3H)-benzoxazolone (300 mg) and potassium carbonate (529 mg) in dimethylformamide (3 ml) was added methyl iodide at ambient temperature, and the mixture was stirred for 3 hours under nitrogen atmosphere. Water was added to the reaction mixture, and the resulting precipitates were collected by filtration to give 3-methyl-7-(tetrahydropyran-2-yloxy)-2(3H)-benzoxazolone (299 mg).

Workup

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-05f6cd4e581a44c28ad433d8ec7a748f
Source dataset
uspto-grants-2000_07
Patent number
US06083961

Reaction notes

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