反应详情

温度

80 °C

Toluene (1 ml), N,N-dimethylformamide (0.5 ml) and a saturated aqueous sodium hydrogencarbonate solution (0.5 ml) were added to 4-(2-iodo-6-methyl-pyridin-3-yloxy)-6,7-dimethoxy-quinoline (compound 116) (50 mg), tetrakistriphenylphosphine palladium (28 mg), and 4-dimethylaminophenylboronic acid (196 mg) under an argon atmosphere, and the mixture was stirred at 80° C. overnight. The reaction solution was cooled to room temperature, water was then added thereto, and the mixture was extracted with chloroform. The chloroform layer was then washed with water and was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform-methanol to give the title compound (39 mg, yield 80%).

1. temperatureThe reaction solution was cooled to room temperature
2. extractionthe mixture was extracted with chloroform
3. washThe chloroform layer was then washed with water
4. dry with materialwas dried over anhydrous magnesium sulfate
5. customThe solvent was removed by distillation under the reduced pressure
6. customthe residue was purified by column chromatography