Hydrochloric Acid → HCID 18705874, compound

HRID 2287858Notes

Reaction equation

HRID 2287858 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-])=[O:18])=[C:10]([C:14]([O-:16])=O)[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[CH3:23][O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH2:30])=[CH:27][CH:26]=1.Cl>>[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:6][C:7]2=[CH:8][C:9]3[C:17](=[O:18])[N:30]([CH2:29][C:28]4[CH:31]=[CH:32][C:25]([O:24][CH3:23])=[CH:26][CH:27]=4)[C:14](=[O:16])[C:10]=3[CH:11]=[C:12]2[CH2:13]1)[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 754524-MethoxybenzylamineHCID 18705881HCID 18705881, compound

Product 1

HCID 18705874HCID 18705874, compound

Procedure

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.10 g, 0.28 mmol) was treated with p-methoxybenzylamine (0.05 mL, 0.4 mmol). Purification using silica gel, eluting with 5:1 CH2Cl2 /acetone, afforded an oil that was converted to an HCl salt and recrystallized from EtOAc to give 105 as a white solid (m.p. 255-256° C.).

Workup

  1. customPurification
  2. washeluting with 5:1 CH2Cl2 /acetone
  3. customafforded an oil that
  4. customrecrystallized from EtOAc

Sources & evidence

ORD record
ord-b7b633cc2c4d43d8a91f11087fe6fe31
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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