Hydrochloric Acid → HCID 18705916, compound

HRID 2287865Notes

Reaction equation

HRID 2287865 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-])=[O:18])=[C:10]([C:14]([O-])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[C:23]1([CH2:29][CH2:30][CH2:31][NH2:32])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.Cl>>[CH2:20]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:6][C:7]2=[CH:8][C:9]3[C:17](=[O:18])[N:32]([CH2:31][CH2:30][CH2:29][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:14](=[O:15])[C:10]=3[CH:11]=[C:12]2[CH2:13]1)[CH2:21][CH3:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 162593-PhenylpropylamineHCID 18705881HCID 18705881, compound

Product 1

HCID 18705916HCID 18705916, compound

Procedure

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with 3-phenylpropylamine(0.19 mL, 1.4 mmol). Purification using silica gel, eluting with 9:1 CH2Cl2 /acetone, afforded an oil that was converted to an HCl salt and recrystallized from hot MeOH/EtOAc to give 114 as a white solid (m.p. 222-223° C.).

Workup

  1. customPurification
  2. washeluting with 9:1 CH2Cl2 /acetone
  3. customafforded an oil that
  4. customrecrystallized from hot MeOH/EtOAc

Sources & evidence

ORD record
ord-f3d6cfc69c8c4807b1de29036fdb37b9
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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