Hydrochloric Acid → HCID 18705822, compound

HRID 2287884Notes

Reaction equation

HRID 2287884 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-:19])=O)=[C:10]([C:14]([O-])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].Cl.Cl.[CH2:25]([NH:32][NH2:33])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.Cl>CC(O)=O>[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:6][C:7]2=[CH:8][C:9]3[C:17](=[O:19])[N:32]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[NH:33][C:14](=[O:15])[C:10]=3[CH:11]=[C:12]2[CH2:13]1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 146540Benzylhydrazine dihydrochlorideHCID 18705881HCID 18705881, compound

Product 1

HCID 18705822HCID 18705822, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using procedure 51, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.349 g, 1 mmol) was treated with benzylhydrazine dihydrochloride (0.27 g, 1.4 mmol) in HOAc (20 mL) Purification using silica gel, eluting with 19:1 CH2Cl2 /MeOH, afforded a solid that was converted to an HCl salt and recrystallized from EtOAc/MeOH to give 135 as a white solid (m.p. 219-220° C.).

Workup

  1. washeluting with 19:1 CH2Cl2 /MeOH
  2. customafforded a solid
  3. customrecrystallized from EtOAc/MeOH

Sources & evidence

ORD record
ord-2d69706388324335aa57f6098cf77771
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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