Hydrochloric Acid → HCID 18702923, compound

HRID 2287945Notes

Reaction equation

HRID 2287945 reaction equation
C[O:2][C:3]([CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([C:17]([O:19][CH3:20])=[O:18])[CH:11]=[CH:10]2)=[O:4].[OH-].[K+].Cl>O.CN(C=O)C>[C:3]([CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([C:17]([O:19][CH3:20])=[O:18])[CH:11]=[CH:10]2)([OH:4])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18702924Methyl 6-methoxycarbonylmethoxy-2-naphthoate

Product 1

HCID 18702923HCID 18702923, compoundYield 77.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

2.3 g of methyl 6-methoxycarbonylmethoxy-2-naphthoate and 2.3 g of KOH are heated under reflux for 3 h in 100 ml of water and 10 ml of DMF. The mixture is then acidified to pH 0.3 using hydrochloric acid, and the precipitate which is deposited is filtered off with suction at RT. 1.7 g of methyl 6-carboxymethoxy-2-naphthoate are obtained;

Workup

  1. filtrationthe precipitate which is deposited is filtered off with suction at RT

Sources & evidence

ORD record
ord-d3d17103bee14f2f937b0e763bf25885
Source dataset
uspto-grants-2000_07
Patent number
US06087304

Reaction notes

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