Methyl iodide → HCID 86755501, compound

HRID 2288012Notes

Reaction equation

HRID 2288012 reaction equation
[CH3:1][N:2]1[C@H:16]2[C@@:6]([O:18][CH3:19])([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@:4]([C:21]2[N:25]=[C:24]([C:26]3[CH:27]=[N:28][CH:29]=[C:30]([Br:32])[CH:31]=3)[O:23][N:22]=2)([CH3:20])[CH2:3]1.[Na].[CH3:34]I>CS(C)=O>[CH3:34][N:12]1[C:11]2[C:17]3[C:14]([CH2:15][C@@H:16]4[C@@:6]([O:18][CH3:19])([C:7]=3[CH:8]=[CH:9][CH:10]=2)[CH2:5][C@@:4]([C:21]2[N:25]=[C:24]([C:26]3[CH:27]=[N:28][CH:29]=[C:30]([Br:32])[CH:31]=3)[O:23][N:22]=2)([CH3:20])[CH2:3][N:2]4[CH3:1])=[CH:13]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5360545SodiumHCID 86755502HCID 86755502, compound

Product 1

HCID 86755501HCID 86755501, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

To a stirred solution of 2 g of 6-methyl-8β-methyl-[5-(5-bromo-pyridin-3-yl)-1,2,4-oxadiazol-3-yl]-10α-methoxy-ergoline in ml 30 of dimethylsulphoxide was added at room temperature, 0.5 g of finely ground sodium hydroxyde. After stirring for 30 mins., a solution of 0.9 g of methyl iodide in m 10 of dimethylsulphoxide was added and the stirring was continued for 1 hour.

Workup

  1. waitthe stirring was continued for 1 hour

Sources & evidence

ORD record
ord-b80ef449daab4d658996f4ff04ad425c
Source dataset
uspto-grants-2000_07
Patent number
US06087371

Reaction notes

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