Hydrochloric Acid → HCID 86584239, compound

HRID 2288209Notes

Reaction equation

HRID 2288209 reaction equation
[F:1][C:2]([F:42])([F:41])[C:3]1[CH:4]=[C:5]([CH:34]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:36]=1)[C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]#[C:17][CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH2:10][C@H:9]1[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[C:28]([CH3:33])[CH:27]=1)=[O:7].[ClH:43]>C(OCC)(=O)C>[ClH:43].[ClH:43].[F:40][C:37]([F:38])([F:39])[C:35]1[CH:34]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:42])[F:41])[CH:36]=1)[C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]#[C:17][CH2:18][N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[CH2:10][C@H:9]1[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[C:28]([CH3:33])[CH:27]=1)=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54528157HCID 54528157, compound

Product 1

HCID 86584239HCID 86584239, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-(5-morpholino-3-pentynyl)piperazine (200 mg) was treated with 4N hydrogen chloride in ethyl acetate solution to give (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-(5-morpholino-3-pentynyl)piperazine Dihydrochloride.

Sources & evidence

ORD record
ord-bb348a3c20054e198953f09e32eda7bf
Source dataset
uspto-grants-2000_07
Patent number
US06087357

Reaction notes

Loading…