反应详情

温度

140 °C

Dimethyl sulfoxide (2.8 ml) was added to 5,6,5′-trimethyl-[2,2′]bipyridin-3-ol (60 mg), 4-chloro-6,7-dimethoxyquinoline (184 mg), cesium carbonate (274 mg), 4-(N,N-dimethylamino)-pyridine (51 mg), and cesium fluoride (64 mg) to prepare a solution which was then stirred at 140° C. overnight. The reaction solution was cooled to room temperature, water was then added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-methanol to give the title compound (33 mg, yield 29%).

1. customto prepare a solution which
2. temperatureThe reaction solution was cooled to room temperature
3. extractionthe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was then washed with water
5. dry with materialwas dried over anhydrous sodium sulfate
6. customThe solvent was removed by distillation under the reduced pressure
7. customthe residue was purified by thin layer chromatography