Hydrochloric Acid → HCID 18412720, compound

HRID 2288481Notes

Reaction equation

HRID 2288481 reaction equation
[CH2:1]([N:4]([CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:5]([C:7]1[CH:26]=[CH:25][C:10]2[N:11]([CH3:24])[C:12]([CH2:14][NH:15][C:16]3[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=3)=[N:13][C:9]=2[CH:8]=1)=[O:6])[C:2]#[CH:3].[ClH:34].C(O)C.C(=O)([O-])[O-].[NH4+:42].[NH4+]>ClCCl.C(O)C>[ClH:34].[CH2:1]([N:4]([CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:5]([C:7]1[CH:26]=[CH:25][C:10]2[N:11]([CH3:24])[C:12]([CH2:14][NH:15][C:16]3[CH:21]=[CH:20][C:19]([C:22](=[NH:42])[NH2:23])=[CH:18][CH:17]=3)=[N:13][C:9]=2[CH:8]=1)=[O:6])[C:2]#[CH:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 517111Ammonium CarbonateHCID 18412640HCID 18412640, compound

Product 1

HCID 18412720HCID 18412720, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-propargyl-N-(2-ethoxycarbonylethyl)-amide, ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 81% of theory, C25H28N6O3 (460.6) Rf value: 0.094 (silica gel; dichloromethane/ethanol=4:1) ##EQU94##

Sources & evidence

ORD record
ord-825d21a1ccca40e38d8ecccc749af708
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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