Hydrochloric Acid → HCID 18412630, compound

HRID 2288499Notes

Reaction equation

HRID 2288499 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15]3)(=[O:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:23][NH:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]#[N:32])=[CH:27][CH:26]=1.[ClH:33].C(=O)([O-])[O-].[NH4+:38].[NH4+]>C(O)C>[ClH:33].[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15]3)(=[O:12])=[O:13])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:31](=[NH:38])[NH2:32])=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 517111Ammonium CarbonateHCID 18412586HCID 18412586, compound

Product 1

HCID 18412630HCID 18412630, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-5-(isoindolin-2-yl-sulphonyl)-benzimidazole and ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 33% of theory, Rf value: 0.32 (silica gel; dichloromethane/methanol=4:1) C24H24N6O2S (460.6) EKA mass spectrum: (M+H)+ =461

Sources & evidence

ORD record
ord-50ea38eb06cb4f1e9ca34285422a129d
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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