4-Methoxybenzoic Acid → HCID 9886132, compound

HRID 2288587Notes

Reaction equation

HRID 2288587 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:14]3[S:15][CH:16]=[CH:17][C:13]=3[CH2:12][CH2:11][NH:10]2)=[CH:5][CH:4]=1.[CH3:18][O:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1>C1(C)C=CC=CC=1.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[C:14]3[S:15][CH:16]=[CH:17][C:13]=3[CH2:12][CH2:11][N:10]2[C:24]([C:23]2[CH:27]=[CH:28][C:20]([O:19][CH3:18])=[CH:21][CH:22]=2)=[O:25])=[CH:7][CH:8]=1

Participants

7

Reactant 4

HCID 74784-Methoxybenzoic AcidHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 18699629HCID 18699629, compound

Product 1

HCID 9886132HCID 9886132, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6228DimethylformamideSolvent

Procedure

7-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (80 mg) in toluene (10 ml), 4-methoxybenzoic acid (55 mg), EDAC (94 mg) and HOBt (44 mg) were mixed in DMF (3 ml). The mixture was stirred overnight, evaporated to dryness and dissolved in ethyl acetate (10 ml).

Workup

  1. customevaporated to dryness
  2. dissolutiondissolved in ethyl acetate (10 ml)

Sources & evidence

ORD record
ord-c8fae2872098471eb8a58bcfb076588a
Source dataset
uspto-grants-2000_07
Patent number
US06090797

Reaction notes

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