p-Anisoyl chloride → HCID 9929318, compound

HRID 2288589Notes

Reaction equation

HRID 2288589 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:13]3[S:14][CH:15]=[CH:16][C:12]=3[CH2:11][CH2:10][N:9]=2)[CH2:4][CH2:3]1.[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH:8]2[C:13]3[S:14][CH:15]=[CH:16][C:12]=3[CH2:11][CH2:10][N:9]2[C:23]([C:22]2[CH:26]=[CH:27][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)=[O:24])[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 18699630HCID 18699630, compound

Product 1

HCID 9929318HCID 9929318, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-(1-Methylpiperidin-4-yl)-4,5,-dihydrothieno[2,3-c]pyridine (0.1 g), 4-methoxybenzoyl chloride (0.086 g), and triethylamine (0.112 ml ) were reacted in toluene (5 ml) exactly as described in example 4. Yield 90% of crude [7-(1-Methylpiperidin-4-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl]-(4-methoxyphenyl)-methanone. MS: M+=370.

Sources & evidence

ORD record
ord-a32e187f9c6942848aa040bcbe380752
Source dataset
uspto-grants-2000_07
Patent number
US06090797

Reaction notes

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