Toluene → HCID 18699636, compound

HRID 2288590Notes

Reaction equation

HRID 2288590 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][CH2:7][NH:8][C:9](C2CCOC2)=O)=[CH:2]1.[O:16]=P(Cl)(Cl)Cl.[C:21]1(C)C=C[CH:24]=[CH:23][CH:22]=1>>[O:16]1[CH2:24][CH2:23][CH:22]([CH:6]2[CH2:7][N:8]=[CH:9][C:2]3[S:1][CH:5]=[CH:4][C:3]2=3)[CH2:21]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 24813Phosphorus oxychlorideHCID 53707289HCID 53707289, compound

Product 1

HCID 18699636HCID 18699636, compound

Procedure

Tetrahydro-3-furoic acid (2-thiophen-3-yl-ethyl)-amide(3.35 g), POCl3 (4.06 ml) were reacted in toluene (150 ml) exactly as described in example 4. 2.77 g of 4-tetrahydrofuran-3-yl-4,5,-dihydrothieno[2,3-c]pyridine was isolated identified by NMR and MS: M+=207.

Sources & evidence

ORD record
ord-a4fd1d8956814a34bd6fa9bdbae240d2
Source dataset
uspto-grants-2000_07
Patent number
US06090797

Reaction notes

Loading…