Dimethylformamide → HCID 70295369, compound

HRID 2288610Notes

Reaction equation

HRID 2288610 reaction equation
[N:1]1([CH2:8][C:9]2[S:13][C:12](C(N)=O)=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CO[CH:19](OC)[N:20]([CH3:22])[CH3:21].C[N:26](C)C=O>>[CH3:21][N:20]([CH3:22])[CH:19]=[N:26][C:12]1[S:13][C:9]([CH2:8][N:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]2)=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 78373Dimethylformamide dimethyl acetalHCID 18700059HCID 18700059, compound

Product 1

HCID 70295369HCID 70295369, compound

Conditions

Temperature
80 °C

Procedure

3.72 g (15.65 mmol) of 5-[(hexahydro-1H-azepin-1-yl)methyl]thiophene-2-carboxamide was dissolved in 30 ml of N,N-dimethylformamide, 3.4 ml (25.6 mmol) of N,N-dimethylformamide dimethylacetal was added, and the mixture was stirred at 80° C. for 4 hours. The reaction solution was concentrated under a reduced pressure, and the resulting residue was dissolved in chloroform, washed with water and then dried over anhydrous magnesium sulfate. By evaporating the solvent, 3.82 g of the title compound was obtained.

Workup

  1. concentrationThe reaction solution was concentrated under a reduced pressure
  2. dissolutionthe resulting residue was dissolved in chloroform
  3. washwashed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customBy evaporating the solvent

Sources & evidence

ORD record
ord-2e2d5df5c4954a1d8a822248d1d71d30
Source dataset
uspto-grants-2000_07
Patent number
US06090804

Reaction notes

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