反应详情

4-Methoxy-3-methylaniline (45.2 g) was dissolved in isopropanol (100 ml) to prepare a solution. Diethyl ethoxymethylenemalonate (71.3 g) was added to the solution, and the mixture was heated under reflux for 5 min. The reaction solution was cooled, and the solvent was then removed by distillation under the reduced pressure. The residue was washed with ether-hexane to give diethyl 2-[(4-methoxy-3-methyl-phenylamino)-methylene]-malonate (76.9 g, yield 76%).

1. customto prepare a solution
2. temperaturethe mixture was heated
3. temperatureunder reflux for 5 min
4. temperatureThe reaction solution was cooled
5. customthe solvent was then removed by distillation under the reduced pressure
6. washThe residue was washed with ether-hexane