反应详情

6-Methoxy-7-methyl-quinoline (3 g) was added to an aqueous bromic acid solution (30 ml), and the mixture was heated under reflux for 7 hr. The reaction solution was cooled to room temperature, the aqueous layer was then neutralized with an aqueous sodium hydroxide solution and an aqueous sodium hydrogencarbonate solution. The organic layer was extracted with ether, the solvent was removed by distillation under the reduced pressure, and the residue was washed with cooled ether to give 6-hydroxy-7-methylquinoline (1.3 g, yield 47%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 7 hr
3. extractionThe organic layer was extracted with ether
4. customthe solvent was removed by distillation under the reduced pressure
5. washthe residue was washed with cooled ether