1,1'-Carbonyldiimidazole → HCID 54189816, compound

Temperature

23 °C

A suspension of 1-acetyl-4-piperidine carboxylic acid (93 g, 542 mmol) in CH2Cl2 (700 mL) is treated portionwise at 23° C. with carbonyldiimidazole (80 g, 542 mmol). The solution is allowed to stir at 23° C. under N2 for 1.5 h, then treated with 2-aminoacetophenone hydrochloride (93 g, 542 mmol) and diisopropylethylamine (113 mL, 650 mmol). The orange solution is stirred for 15 h, then washed with 2 N NaOH (2×200 mL), 2 N HCl (2×200 mL), and brine (1×300 mL), dried (MgSO) and concentrated to a red solid. The solid is dissolved in hot MeOH, and addition of hexane gave a pale orange solid which is obtained by filtration. The mother liquid is concentrated, the residue taken up in hot MeOH, and another crop of product is obtained by addition of hexane, to give a combined yield of 122 g of 1-Acetyl-piperidine-4-carboxylic acid (2-oxo-2-phenyl-ethyl)-amide as a pale orange solid.

1. stirringThe orange solution is stirred for 15 h
2. washwashed with 2 N NaOH (2×200 mL), 2 N HCl (2×200 mL), and brine (1×300 mL)
3. dry with materialdried (MgSO)
4. concentrationconcentrated to a red solid
5. dissolutionThe solid is dissolved in hot MeOH
6. additionaddition of hexane
7. customgave a pale orange solid which
8. customis obtained by filtration
9. concentrationThe mother liquid is concentrated
10. customanother crop of product is obtained by addition of hexane

ORD record

ord-7ff169579ce64b41b58793e9cb4c4058

Source dataset

uspto-grants-2000_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06090825