反应详情

5-(2-chloro-ethyl)-2-methoxy-benzenesulfonyl chloride (5.78 g, 21.5 mmol) is dissolved in dioxane (72 mL). To this solution is added glycinamide hydrochloride (4.75 g, 42.9 mmol) and N,N-diisopropylethylamine (7 mL, 42.9 mmol) with stirring at room temperature for 24 h. The solution is diluted with ethyl acetate (100 mL) and washed with 1 M H3PO4 (2×50 mL), sat NaHCO3, (1×50 mL,) brine (1×50 mL). The organic phase is dried with Na2SO4, filtered and the volatiles concentrated to a white solid. The solid is collected on a buchner by vacuum filtration and washed with ether to provide the title compound.

1. washwashed with 1 M H3PO4 (2×50 mL)
2. dry with materialThe organic phase is dried with Na2SO4
3. filtrationfiltered
4. concentrationthe volatiles concentrated to a white solid
5. filtrationThe solid is collected on a buchner by vacuum filtration
6. washwashed with ether