Trifluoroacetic acid → HCID 86755555, compound

HRID 2289072Notes

Reaction equation

HRID 2289072 reaction equation
[CH3:1][N:2]([CH2:32][C:33]([NH:35][C@H:36]1[CH2:40][CH2:39][N:38](C(OC(C)(C)C)=O)[CH2:37]1)=[O:34])[C:3]([NH:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)=[O:20])=[N:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=[O:6].[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51]>ClCCl>[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51].[CH3:1][N:2]([CH2:32][C:33]([NH:35][C@H:36]1[CH2:40][CH2:39][NH:38][CH2:37]1)=[O:34])[C:3]([NH:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)=[O:20])=[N:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=[O:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57034816HCID 57034816, compound

Product 1

HCID 86755555HCID 86755555, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound (1.48 g), which had been obtained in (1), in anhydrous dichloromethane (8 ml), trifluoroacetic acid (4 ml) was added dropwise under ice cooling. The reaction mixture was then treated in a similar manner to that described in Referential Example 16-(2), whereby the title compound was obtained. The product was provided for use in the subsequent reaction without isolation.

Workup

  1. additionThe reaction mixture was then treated in a similar manner to that

Sources & evidence

ORD record
ord-482e5d41b60947969276c8d78c424658
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

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