反应详情

A solution of 3-(2,2-dimethylpropyl)-6-hydroxy-7-propylbenz[4,5]isoxazole (2.000 grams; 8.090 mmol) in dry DMF (20 mL) was treated with 1,3-dibromopropane (4.29 mL; 42.263 mmol). Cesium carbonate (2.900 grams; 8.901 mmol) was added and the mixture stirred at 20° for 8 hours. The reaction mixture was partitioned between isopropyl acetate and pH 4 buffer. The organic was washed with water, then dried over magnesium sulfate. Filtration and evaporation afforded an oil which was chromatographed over silica gel, giving the title compound.

1. customThe reaction mixture was partitioned between isopropyl acetate and pH 4 buffer
2. washThe organic was washed with water
3. dry with materialdried over magnesium sulfate
4. filtrationFiltration and evaporation
5. customafforded an oil which
6. customwas chromatographed over silica gel