反应详情

温度

60 °C

Propyl 3-[7-(3-chloro-propoxy)-6-methoxy-quinolin-4-yloxy]-naphthalene-2-carboxylate (compound 325) (110 mg) was dissolved in N,N-dimethylformamide (3 ml) to prepare a solution. Potassium carbonate (317 mg) and imidazole (78 mg) were added to the solution, and the mixture was stirred at 60° C. overnight. Water was added to the reaction solution, and the mixture was extracted with chloroform. The chloroform layer was then washed with saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-methanol to give the title compound (97 mg, yield 82%).

1. customto prepare a solution
2. extractionthe mixture was extracted with chloroform
3. washThe chloroform layer was then washed with saturated brine
4. dry with materialwas dried over anhydrous sodium sulfate
5. customThe solvent was removed by distillation under the reduced pressure
6. customthe residue was purified by thin layer chromatography