4-Nitrobenzoyl chloride → HCID 21932475, compound

Temperature

0 °C

Lithium diisopropylamide (121.0 mL of a 2.0M solution, 0.243 mol) is placed into a 500 mL three-necked round-bottomed flask fitted with a magnetic stirrer, internal thermometer, argon inlet, and addition funnel. The flask is placed in a dry ice-acetone bath. 2,6-Dimethyl-7-octen-2-yl acetate (22.66 g, 0.114 mol) is dissolved in THF (5 mL) and the resulting solution added to the flask over 45 min. Once addition is complete, the mixture is stirred for an additional 15 min. before being treated with a solution of 4-nitrobenzoyl chloride (20.00 g, 0.108 mol) dissolved in THF (25 mL) over 30 min. The mixture is warned to -20° C. and stirred at that temperature for 18 h. After warming to 0° C., the mixture is quenched with 20% HCl (70 mL). The mixture is poured into a separatory funnel containing ether (150 mL) and water (250 mL). The aqueous layer is extracted with ether (150 mL). The combined organic layers are washed with saturated NaHCO3 solution (2×100 mL), water (2×150 mL) and brine (150 mL), dried over MgSO4 and filtered. The solvent is removed by rotary evaporation to give an orange/red oil. The oil is purified by column chromatography (elution with 2% ethyl acetate/petroleum ether) to yield a colorless oil having 1H and 13C NMR spectra consistent with the desired product.

1. customfitted with a magnetic stirrer
2. additioninternal thermometer, argon inlet, and addition funnel
3. customThe flask is placed in a dry ice-acetone bath
4. additionthe resulting solution added to the flask over 45 min
5. additionOnce addition
6. customis warned to -20° C.
7. stirringstirred at that temperature for 18 h
8. customthe mixture is quenched with 20% HCl (70 mL)
9. additionThe mixture is poured into a separatory funnel
10. additioncontaining ether (150 mL) and water (250 mL)
11. extractionThe aqueous layer is extracted with ether (150 mL)
12. washThe combined organic layers are washed with saturated NaHCO3 solution (2×100 mL), water (2×150 mL) and brine (150 mL)
13. dry with materialdried over MgSO4
14. filtrationfiltered
15. customThe solvent is removed by rotary evaporation
16. customto give an orange/red oil
17. customThe oil is purified by column chromatography (elution with 2% ethyl acetate/petroleum ether)
18. customto yield a colorless oil

ORD record

ord-dc41d36ee34842efb4aa07a16c94c259

Source dataset

uspto-grants-2000_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06093691