Hydrochloric Acid → HCID 18698038, compound

HRID 2289547Notes

Reaction equation

HRID 2289547 reaction equation
[ClH:1].[Br:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:17][CH2:16][N:15]([C:18]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[O:19])[CH2:14][CH2:13]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1>C(OCC)(=O)C>[ClH:1].[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([N:12]2[CH2:17][CH2:16][N:15]([C:18]([N:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]3)=[O:19])[CH2:14][CH2:13]2)(=[O:10])=[O:11])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18697987HCID 18697987, compound

Product 1

HCID 18698038HCID 18698038, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution (200 ml) of ethyl acetate saturated with hydrogen chloride was added to a mixture of 1-(4-bromophenylsulphonyl)-4-[1-(t-butoxycarbonyl)piperazin-4-ylcarbonyl]piperazine and ethyl acetate (200 ml) . The mixture was stirred overnight. The solvent was removed by evaporation to give 1-(4-bromophenylsulphonyl)-4-(1-piperazinylcarbonyl)piperazine hydrochloride (16.30 g).

Workup

  1. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-fa35cc69d78f49b1b8a91ff4ad393f9b
Source dataset
uspto-grants-2000_07
Patent number
US06093718

Reaction notes

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