反应详情

温度

80 °C

N,N-Dimethylformamide (1 ml) was added to 7-(2-chloro-ethoxy)-6-methoxy-4-(2-methyl-quinolin-3-yloxy)-quinoline (compound 353) (50 mg), potassium carbonate (53 mg), and piperidin-3-yl-methanol (44 mg), and the mixture was stirred at 80° C. overnight. The reaction solution was then stirred at 100° C. for one day, and the reaction solution was cooled to room temperature. Water was added thereto, and the mixture was extracted with chloroform. The chloroform layer was washed with water and was then dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give the title compound (33 mg, yield 55%).

1. stirringThe reaction solution was then stirred at 100° C. for one day
2. temperaturethe reaction solution was cooled to room temperature
3. extractionthe mixture was extracted with chloroform
4. washThe chloroform layer was washed with water
5. dry with materialwas then dried over anhydrous sodium sulfate
6. customThe solvent was removed by distillation under the reduced pressure
7. customThe residue was purified by thin layer chromatography