HCID 178453399, compound → HCID 178512675, compound

HRID 2289779Notes

Reaction equation

HRID 2289779 reaction equation
C([O:5][C:6](=[O:39])[C@H:7]([CH2:27][CH2:28][CH2:29][CH2:30][NH:31]C(OC(C)(C)C)=O)[NH:8][S:9]([C:12]1[CH:21]=[C:20]2[C:15]([C:16]([Cl:26])=[CH:17][N:18]=[C:19]2[NH:22][C:23]([NH2:25])=[NH:24])=[CH:14][CH:13]=1)(=[O:11])=[O:10])(C)(C)C>CCOC(C)=O.Cl>[Cl:26][C:16]1[C:15]2[C:20](=[CH:21][C:12]([S:9]([NH:8][C@H:7]([C:6]([OH:39])=[O:5])[CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])(=[O:10])=[O:11])=[CH:13][CH:14]=2)[C:19]([NH:22][C:23]([NH2:25])=[NH:24])=[N:18][CH:17]=1

Participants

4

Reactant 1

HCID 178453399HCID 178453399, compound

Product 1

HCID 178512675HCID 178512675, compoundYield 15%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

Nα-[(4-Chloro-1-guanidino-7-isoquinolinyl) sulphonyl]-Nε-tert-butyloxycarbonyl-L-lysine tert-butyl ester (119 mg, 0.20 mmol) was dissolved in EtOAc (10 ml) and saturated with gaseous HCl. After 20 min, the resultant white precipitate was obtained by filtration and recrystallised from EtOH to give Nα-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-lysine (13 mg, 0.03 mmol).

Workup

  1. customthe resultant white precipitate was obtained by filtration
  2. customrecrystallised from EtOH

Sources & evidence

ORD record
ord-85bf1e11c9f3455685cf3ce781adf766
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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