Hydrochloric Acid → HCID 18698220, compound

HRID 2289796Notes

Reaction equation

HRID 2289796 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:12]([N:15]([CH2:24][CH2:25][O:26]C3CCCCO3)[C:16]3([C:21]([OH:23])=O)[CH2:20][CH2:19][CH2:18][CH2:17]3)(=[O:14])=[O:13])=[CH:9][CH:10]=2)[C:5]([NH:33][C:34]([NH2:36])=[NH:35])=[N:4][CH:3]=1.Cl>CCOC(C)=O>[ClH:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:12]([N:15]3[CH2:24][CH2:25][O:26][C:21](=[O:23])[C:16]43[CH2:17][CH2:18][CH2:19][CH2:20]4)(=[O:14])=[O:13])=[CH:9][CH:10]=2)[C:5]([N:33]=[C:34]([NH2:35])[NH2:36])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178512668HCID 178512668, compound

Product 1

HCID 18698220HCID 18698220, compoundYield 1,945.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-{[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl][2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}cyclopentanecarboxylic acid (20 mg, 0.037 mmol) was dissolved in EtOAc (20 ml), ethereal HCl (10 ml) added, and the reaction stirred at room temperature for 18 h. The resulting precipitate was filtered, washed with EtOAc and dried under vacuum to give N"-{4-Chloro-7-[(10-oxo-9-oxa-6-azaspiro[4.5]dec-6-yl)sulphonyl]-1-isoquinolinyl}guanidine hydrochloride (17 mg, 0.36 mmol).

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with EtOAc
  3. customdried under vacuum

Sources & evidence

ORD record
ord-463983c491f54b3794c398df6550c29d
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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