Hydrochloric Acid → Ethyl 1-aminocyclobutane-1-carboxylate hydrochloride

HRID 2289810Notes

Reaction equation

[NH2:1][C:2]1([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:5][CH2:4][CH2:3]1.NC1(C(O)=O)CCC1.[ClH:19]>CCO>[ClH:19].[NH2:1][C:2]1([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:5][CH2:4][CH2:3]1

Participants

Conditions

Temperature: 23 °C

Procedure

Ethyl 1-aminocyclobutanecarboxylate ##STR153## A solution 1-aminocyclobutanecarboxylic acid (500 mg, 4.34 mmol) in EtOH (10 mL) was saturated with HCl gas, and the mixture was stirred at 23° C. for 4 d. The solvents were vaporated in vacuo, azeotroping with PhMe and CH2Cl2, to give ethyl 1-aminocyclobutanecarboxylate hydrochloride (754 mg, 4.20 mmol) as an off-white solid.

Workup

customazeotroping with PhMe and CH2Cl2

Sources & evidence

ORD record: ord-f3f57362f4b649779e3d4e9ee339f4ce
Source dataset: uspto-grants-2000_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06093731

Reaction notes

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