Phosphorus oxychloride → HCID 18698144, compound

HRID 2289832Notes

Reaction equation

HRID 2289832 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH:13]([CH3:15])[CH3:14])[CH:10]=2)[C:5](=O)[NH:4][C:3]=1[C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18].P(Cl)(Cl)([Cl:26])=O>CCCCCCC.C(OCC)(=O)C>[Cl:26][C:5]1[C:6]2[C:11](=[CH:10][C:9]([O:12][CH:13]([CH3:15])[CH3:14])=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[N:4]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 54729592HCID 54729592, compound

Product 1

HCID 18698144HCID 18698144, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

2.0 g of compound B from Example 1e) were reacted with phosphorus oxychloride analogously to 1f). After chromatography using heptane/ethyl acetate (4:1) on silica gel, 1.5 g of product were isolated; m.p. 116-118° C. (from petroleum ether).

Sources & evidence

ORD record
ord-910cec84c56e4d939581817011ba2744
Source dataset
uspto-grants-2000_07
Patent number
US06093730

Reaction notes

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