Sarcosine → Creatine

HRID 2289872Notes

Reaction equation

HRID 2289872 reaction equation
[NH:1]([CH2:3][C:4]([OH:6])=[O:5])[CH3:2].Cl.CO[C:10](=[NH:12])[NH2:11]>>[O:5]=[C:4]([CH2:3][N:1]([C:10](=[NH:11])[NH2:12])[CH3:2])[OH:6]

Participants

3

Reactant 2

HCID 1088SarcosineHCID 3083899Carbamimidic acid, methyl ester, hydrochloride (1:1)

Product 1

HCID 586Creatine

Procedure

The reaction of sarcosine with O-methylisourea hydrochloride, described by E. Schutte in Hoppe-Seylers Z. Physiol. Chemie 279 (1943) 52-59, affords creatine in a yield of only 21%.

Sources & evidence

ORD record
ord-25f04663b0a8469da830c9806ac11aa1
Source dataset
uspto-grants-2000_07
Patent number
US06093848

Reaction notes

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