Acetic Acid → HCID 20231959, compound

HRID 2290227Notes

Reaction equation

HRID 2290227 reaction equation
C(C1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH:7]([CH3:13])[CH2:6]2)#N.[C:14]([OH:17])(=[O:16])[CH3:15].Cl>C(O)C>[C:14]([C:15]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH:7]([CH3:13])[CH2:6]2)([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 14853009HCID 14853009, compound

Product 1

HCID 20231959HCID 20231959, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of 5-cyano-2-methylindan-1-one (9.36 g), glacial acetic acid (90 ml) and concentrated hydrochloric acid (90 ml) was heated under reflux for 20 hours to afford 5-carboxy-2-methylindan-1-one, m.p. 189°-194° C. (from aqueous ethanol).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 20 hours

Sources & evidence

ORD record
ord-9a2cf8d5aeaf456ea8153ec2013d8978
Source dataset
uspto-grants-1986_10
Patent number
US04616013

Reaction notes

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